Rapid Decline of Influenza Vaccine—Induced Antibody in the Elderly: Is It Real, or Is It Relevant?
Identifieur interne : 001293 ( Main/Exploration ); précédent : 001292; suivant : 001294Rapid Decline of Influenza Vaccine—Induced Antibody in the Elderly: Is It Real, or Is It Relevant?
Auteurs : Danuta M. Skowronski [Canada] ; S. Aleina Tweed ; S. Aleina Tweed ; Gaston De Serres [Canada]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2008.
Abstract
Advisory committees have cautioned that influenza vaccine-induced antibody declines more rapidly in the elderly, falling below seroprotective levels within 4 months.Weconducted a literature review to assess this assertion. The articles that were included in this review reported antibody levels ⩾4 months after influenza immunization in persons ⩾60 years old, interpretable in the Medicinal Products (CPMP) for the elderly. The final review included 14 studies; 8 of which reported seroprotection rates. Seroprotection exceedingCPMPcriteria was maintained ⩾4 months after influenza immunization in all 8 of the studies reporting this for the H3N2 component and in 5 of the 7 studies reporting this for the H1N1 and B components. In determining whether CPMP criteria were met at season's end, primary antibody response appeared to be more relevant than secondary antibody decline. Both studies reporting seroprotection rates that failed CPMP criteria ⩾4 months after influenza immunization for each of the H1N1 and B components had also reported failed seroprotection at 1 month after immunization. If initially achieved after immunization, seroprotection rates of 70%–100% were maintained not just at 4 months (2 studies) but also at 5 months (2 studies) and even at >6 months (4 studies), for the H3N2 and H1N1 vaccine components. Seroprotection rates appeared less consistent for the B vaccine component, throughout the postimmunization period. Seroconversion appears to vary substantially and inversely with preimmunization titers but not with age. In 2 of 6 studies reporting seroconversion alone,CPMPcriteria were still met at 4 months. In the other 4 studies, the main reason for failure at 4 months was primary failure at 1 month. A total of 6 studies compared antibody persistence by age, and no consistent differences were found on that basis. The historic concern that the influenza vaccine-induced antibody response in the elderly declines more rapidly and below seroprotective levels within 4 months of immunization should be reconsidered.
Url:
DOI: 10.1086/524146
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001709
- to stream Istex, to step Curation: 001709
- to stream Istex, to step Checkpoint: 000326
- to stream Main, to step Merge: 001306
- to stream Main, to step Curation: 001293
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Rapid Decline of Influenza Vaccine—Induced Antibody in the Elderly: Is It Real, or Is It Relevant?</title>
<author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
</author>
<author><name sortKey="Tweed, S Aleina" sort="Tweed, S Aleina" uniqKey="Tweed S" first="S. Aleina" last="Tweed">S. Aleina Tweed</name>
</author>
<author><name sortKey="Tweed, S Aleina" sort="Tweed, S Aleina" uniqKey="Tweed S" first="S. Aleina" last="Tweed">S. Aleina Tweed</name>
</author>
<author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:56FBEDB5DF2B07C415B66025FBBD849B8D586891</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1086/524146</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-DPPWCT9L-M/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001709</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001709</idno>
<idno type="wicri:Area/Istex/Curation">001709</idno>
<idno type="wicri:Area/Istex/Checkpoint">000326</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000326</idno>
<idno type="wicri:doubleKey">0022-1899:2008:Skowronski D:rapid:decline:of</idno>
<idno type="wicri:Area/Main/Merge">001306</idno>
<idno type="wicri:Area/Main/Curation">001293</idno>
<idno type="wicri:Area/Main/Exploration">001293</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Rapid Decline of Influenza Vaccine—Induced Antibody in the Elderly: Is It Real, or Is It Relevant?</title>
<author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
<affiliation></affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Canada</country>
</affiliation>
<affiliation wicri:level="1"><country>Canada</country>
<wicri:regionArea>Reprints or correspondence: Danuta M. Skowronski, British Columbia Centre for Disease Control, 655 W. 12th Ave., Vancouver, British Columbia V5Z 4R4</wicri:regionArea>
<wicri:noRegion>British Columbia V5Z 4R4</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tweed, S Aleina" sort="Tweed, S Aleina" uniqKey="Tweed S" first="S. Aleina" last="Tweed">S. Aleina Tweed</name>
<affiliation><wicri:noCountry code="subField">Columbia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tweed, S Aleina" sort="Tweed, S Aleina" uniqKey="Tweed S" first="S. Aleina" last="Tweed">S. Aleina Tweed</name>
<affiliation><wicri:noCountry code="subField">Columbia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Quebec National Institute of Public Health, Montreal, Quebec</wicri:regionArea>
<wicri:noRegion>Quebec</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">The Journal of Infectious Diseases</title>
<title level="j" type="abbrev">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date when="2008-02-15">2008</date>
<biblScope unit="vol">197</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="490">490</biblScope>
<biblScope unit="page" to="502">502</biblScope>
</imprint>
<idno type="ISSN">0022-1899</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Advisory committees have cautioned that influenza vaccine-induced antibody declines more rapidly in the elderly, falling below seroprotective levels within 4 months.Weconducted a literature review to assess this assertion. The articles that were included in this review reported antibody levels ⩾4 months after influenza immunization in persons ⩾60 years old, interpretable in the Medicinal Products (CPMP) for the elderly. The final review included 14 studies; 8 of which reported seroprotection rates. Seroprotection exceedingCPMPcriteria was maintained ⩾4 months after influenza immunization in all 8 of the studies reporting this for the H3N2 component and in 5 of the 7 studies reporting this for the H1N1 and B components. In determining whether CPMP criteria were met at season's end, primary antibody response appeared to be more relevant than secondary antibody decline. Both studies reporting seroprotection rates that failed CPMP criteria ⩾4 months after influenza immunization for each of the H1N1 and B components had also reported failed seroprotection at 1 month after immunization. If initially achieved after immunization, seroprotection rates of 70%–100% were maintained not just at 4 months (2 studies) but also at 5 months (2 studies) and even at >6 months (4 studies), for the H3N2 and H1N1 vaccine components. Seroprotection rates appeared less consistent for the B vaccine component, throughout the postimmunization period. Seroconversion appears to vary substantially and inversely with preimmunization titers but not with age. In 2 of 6 studies reporting seroconversion alone,CPMPcriteria were still met at 4 months. In the other 4 studies, the main reason for failure at 4 months was primary failure at 1 month. A total of 6 studies compared antibody persistence by age, and no consistent differences were found on that basis. The historic concern that the influenza vaccine-induced antibody response in the elderly declines more rapidly and below seroprotective levels within 4 months of immunization should be reconsidered.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><noCountry><name sortKey="Tweed, S Aleina" sort="Tweed, S Aleina" uniqKey="Tweed S" first="S. Aleina" last="Tweed">S. Aleina Tweed</name>
<name sortKey="Tweed, S Aleina" sort="Tweed, S Aleina" uniqKey="Tweed S" first="S. Aleina" last="Tweed">S. Aleina Tweed</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
</noRegion>
<name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001293 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001293 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:56FBEDB5DF2B07C415B66025FBBD849B8D586891 |texte= Rapid Decline of Influenza Vaccine—Induced Antibody in the Elderly: Is It Real, or Is It Relevant? }}
This area was generated with Dilib version V0.6.33. |